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This produces glutamate sensitivity symptoms , including: heightened sensory awareness agitation emotional lability insomnia stress-triggered cognitive freezing amplification of intrusive thoughts Glutamate excess disrupts extinction learning the ability to update or erase old threat associations

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It plays the role of methionine & homocysteine metabolism that affects the energy balance [47]

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Later, Jins group showed that the endogenous H 2 S/CSE pathway was suppressed in MCT-induced PH rats, and exogenous H 2 S reduced pulmonary artery pressure, reversed pulmonary vascular structural remolding by suppressing phosphorylation of NF-B p65 and IB MCT-treated rats (Feng et al., 2017)