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doi:10.5826/dpc.0701a01 Carbone JW, Pasiakos SM

Barger G & Ewins AJ (1911) CCLVII

This direct contact may enhance local tissue effects beyond what systemic administration achieves

RT activates the cGAS-STING pathway in tumor cells, and while dsDNA and cGAMP can be transmitted to myeloid cells through multiple mechanisms to activate their cGAS-STING pathway, this activation is often transient and insufficient