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CRID2 2-hydroxyanthracen-9(10H)-one - a xanthone Mammea from africana, 38% total inhibition at 0.033 mM 2-[(1-methyl-1H-pyrrol-2-ylsulfonyl)methyl]aniline - 28.0% inhibition at 0.1 mM 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8-methyl-1,5,7-tris(3-methylbut-2-en-1-yl)-8-(4-methylpent-3-en-1-yl)bicyclo[3.3.1]non-3-ene-2,9-dione - a benzophenone Garcinia smeathmannii, 41% total inhibition at 0.033 mM 3-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)propane-1-sulfonyl fluoride - - 3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid - - 3-chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-propenamide - - 3-ethyl-2-oxo-3,3a,7a,9b-tetrahydro-2H,4aH-1,4,5-trioxadicyclopenta[a,hi]indene-7-carboxylic acid - an iridoid from Plumeeria rubra, 51% total inhibition at 0.033 mM 4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol - - 4-(acryloylamino)-N-(5-[[5-([5-[(2-carbamimidamidoethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-2-carboxamide - a brostallicin derivative, the debrominated derivative of brostallicin is almost completely ineffective as an inhibitor of GSTP1-1 4-[(2-bromoacryloyl)amino]-N-(5-[[5-([5-[(2-carbamimidamidoethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-2-carboxamide - i.e

In refractory cases, more invasive options may also be considered

Liang Z, Hu H, Li J, et al

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doi: 10.3109/13880209.2013.879188 105 XuYHXiongJFZhaoYHHeBZhengZGChuGJet al