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Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction

Reactive metabolites (such as ROS and electrophiles) can promote adaptive responses through mitochondrial dysfunction, endoplasmic reticulum stress, or DNA damage, thereby increasing molecular chaperone proteins (Figure 3)

Tertiary amine modification enables triterpene nanoparticles to target the mitochondria and treat glioblastoma via pyroptosis induction

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