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This article systematically reviews the progress of photodynamic therapy, the mechanism of action of light-activated prodrugs, the coupling strategies between prodrugs and photosensitizers (including covalent bonds and non-covalent bonds), and the clinical translation challenges of light-activated prodrug systems

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Vitamin B3 (Niacin) Niacin, especially in high doses, can lead to gastrointestinal upset, including nausea and abdominal pain

Indeed, hypoxia contributes to high levels of oxidative stress [42], important in the context of depression, highlighted in this manuscript