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showed that ex20ins in HER2-mutant lung cancers lead to ligand-independent kinase activation by altering the conformational landscape of HER2 kinase and restricting its conformation in the active state

Curcumin exhibits high lipophilicity, and according to the study by Moustapha team (Moustapha et al., 2015), it is rapidly internalized by cells at a ratio of 1/20 relative to its external concentration

[13] [15] Common side effects include local reactions at the injection site, such as pain, swelling, or erythema