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Elbaz A, Bower JH, Maraganore DM, McDonnell SK, Peterson BJ, Ahlskog JE, Schaid DJ, Rocca WA

KU-57788-mediated activation of DRP1 synergistically enhances the sensitivity of ATC cells to ferroptosis Current studies suggest that DRP1-regulated mitochondrial fission dynamics are intricately linked to oxidative stress, with hyperactivation of DRP1 often resulting in excessive mitochondrial fission and fragmentation, elevated ROS levels, and potential cell death [30]

The mucolipin-1 (TRPML1) ion channel, transmembrane-163 (TMEM163) protein, and lysosomal zinc handling

Blockade of USP14 stabilizes K63-linked ubiquitination on IRF3, promoting its phosphorylation/activation and downstream type I IFN signaling in dendritic cells, which synergizes with radiation to enhance systemic antitumor immunity [30]

Nasal Sprays : Nasal B12 sprays have been shown to effectively raise B12 levels and offer a convenient, needle-free alternative for individuals who prefer non-injection options or have difficulty with traditional supplementation[23]