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The simple joys of playing sports, hiking, climbing, walking without orthopedic shoes, strumming his guitar, or writing became distant dreams

phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin (PI3K/AKT/mTOR) pathway, mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway and caspase pathway, and alteration of immune responses (Pagano et al