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Metformin ameliorates oxidative stress induced by diabetes mellitus and hepatocellular carcinoma in rats

Some studies reported increased levels of catalase, whereas others reported downregulation of this enzyme

Wang H, Yang T, Wu J, Chen D, Wang W

The anti-apoptotic protein Bcl-2 suppresses apoptosis induced by pro-apoptotic Bax and directly inhibits caspase family members, including caspase-3 and caspase-9 [39, 40]