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3 System Xc consists of a solute carrier family 7 members 11 (SLC7A11, or xCT) and solute carrier family 3 members 2

Tumour microenvironment (TME)-targeted nanotherapy Reprogramming the TME is a critical direction in nanotherapy, with strategies including immune cell regulation and metabolic intervention

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The comet assay in association with gamma-H2AX foci showed DNA injury, and the overexpression of Bax and PARP1 cleavage showed cellular apoptosis after the combination treatment