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However, recent studies have shown them to be important in modulating the innate immune response [105, 106, 107]

In STZ-diabetic rats, treadmill exercise reduced retinal apoptosis (TUNEL+cells, Bax/Bcl-2 ratio, caspase-3 activation) and restored p-Akt levels in the retina, indicating activation of survival signaling in the diabetic neurovascular unit (242)

Unlike the live SP, which displayed remarkable antioxidant effects and osteoclastogenesis-inhibitory properties, both SP powder and boiled SP lost these biological functions (Supplementary Figs