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During energy stress, an increased AMP/ATP ratio activates AMPK, which promotes autophagy through multiple mechanisms

doi: 10.1016/j.exer.2025.110299 392 LiSLuSWangLLiuSZhangLDuJet al

TCR activation triggers GSH synthesis, influencing T-cell survival and function, while chronic nitro-oxidative stress depletes GSH, compromising metabolic reprogramming and sustaining aerobic glycolysis