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Description

Several studies have confirmed that the hypermethylation of the BNC1 (268), GATA5 (157) and SCUBE3 (156) promoters often predicts poor prognosis of patients with renal cell carcinoma

Densities assigned as RNA are shown in blue

Consequently, the toxic effects of cyclophosphamide are likely due to acrolein that, when coupled with the already increased state of inflammation and oxidative stress in cancer, may exacerbate the oxidative state producing ovarian damage both on the level of the follicles and the oocytes