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Metabolic byproducts such as adenosine, generated via CD39 and CD73 on tumor and stromal cells, engage A2A receptors on T cells, increasing intracellular cAMP levels and suppressing early TCR signaling events [140]

They are identifying a technology they may one day need at scale

Di Monte, DA, Tokar I, Langston JW, Impaired glutamate clearance as a consequence of energy failure caused by MPP(+) in astrocytic cultures

Additionally, the challenges associated with the clinical application of ferroptosis-inducing drugs are discussed, offering valuable insights for the development of novel treatment strategies for BC