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Many larger molecules, including most antibiotics and chemotherapy drugs, are denied entry across the BBB

doi: 10.3390/nu16203454 137 ZhaoRZJiangSZhangLYuZB

Gonadotropin releasing hormone agonists, such as goserelin, are employed to induce a hypoestrogenic state by initially stimulating and then downregulating pituitary hormone secretion, whereas gonadotropin releasing hormone antagonists, directly block receptor binding for a more rapid onset of action (5)

Depot Release for Chronic Conditions: For conditions like melasma or chronic photo-damage, a spike in antioxidant levels is less effective than steady levels