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Description

5.1 Niclosamide solutions can readily be obtained by dissolving niclosamide powder into simple buffer As predicted in Figure 4 , and measured in Figures 7A and 7B , a 20uM niclosamide solution can readily be obtained by dissolving niclosamide powder into aqueous solution at a pH of 7.88

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Intriguingly, while VRK2 wild-type tumors were resistant to APR-017 monotherapy, combinatorial treatment with the VRK2 inhibitor IC261 restored their sensitivity to APR-017 (Fig