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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

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Notably, in SURMOUNT-1, lean mass loss as a proportion of total mass lost was similar (~25%) across the treatment and placebo groups 62 , and in the treatment group, physical function scores were improved relative to baseline and by comparison to the placebo group at the end of the study 62, 63

Glutathione is an antioxidant that can be naturally found in the body