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The estimation of t 1/2eff utilizes the ratio of drug exposure at steady state to drug exposure after the first dose (accumulation ratio, or R ac ), with a higher R ac indicating greater drug accumulation

Analogs of phosphodiester linkages include phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoroanilothioate, phosphoranilidate, phosphoramidate, N3'P5' phosphoramidate and the like

PCA 32, 899906

JAMA 111 , 10851092 (1938)

However, GSH application improved the ABA, JA, and SA levels, which might decrease the oxidative stress caused by Cd through the activation of the AsA-GSH-NADPH cycle to overcome Cd toxicity (Figure 5)