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In contrast, if HCV RNA is still detectable at week 24, the likelihood of an SVR is virtually nil and treatment can be stopped or continued with the only aim to slow liver disease progression in patients with a severe prognosis, without any hope to eradicate infection (Figure 1A) [18, 22 ]

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We therefore present minocycline as negative clinical evidence that nonetheless informed microglial-targeting hypotheses rather than as an effective therapy