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The 12-month trial design enables us to assess senolytic-associated changes before and after treatment during the 3-month active treatment phase, track the reappearance of senescent cells after their removal during the 9-month post-treatment period, and evaluate disease trajectory differences over a one-year period (Figure 3)

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Blood 124(21):3186, 2014

Based on a comprehensive literature review, this paper highlights five principal bioactive classes derived from TCM: glycosides, flavonoids, phenolic compounds, anthraquinones, and terpenoids

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