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Mechanistically, mTORC1 promotes the proteasome-mediated destabilization of CREB2 to suppress SIRT4 (a mitochondria-localized member of the sirtuin family), which inhibits GDH, thereby enhancing GDH enzymatic activity

We found that about 2,000 genes are differentially regulated (false discovery rate less than 5% and log-2 fold change larger than 1) in at least one mutant cell line compared to parental SW48 cells (Figures 1A and S1E-F)

proposed a hypothesis in a mouse model, suggesting oxidative stress in livers with preexisting fatty liver disease might play a role

10.1016/j.jneuroim.2019.577071 104 MoghaddamA

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