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In this study, we show that nearly half of the human thyroid cancer specimens have increased GPX4 expression compared to control normal thyroid tissue and that the GPX4 overexpression is associated with worse overall survival

Overlapping analyses among antibody-based, chemoselective labeling-based K-Hcy proteomics, and the Aging Atlas[40] confirmed a subset of conserved K-Hcy-modified proteins, including High mobility group box-1 and 2 (HMGB1/2) (Figure 4E)

Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes

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In essence, the augmented cisplatin tolerance in ESCC is potentially orchestrated by enhanced platinum efflux, increased glutathione-mediated detoxification, and bolstered antioxidant defenses, collectively mitigating oxidative stress-induced cellular damage and apoptosis