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Dual vascular endothelial growth factor receptor and fibroblast growth factor receptor inhibition elicits antitumor immunity and enhances programmed cell death-1 checkpoint blockade in hepatocellular carcinoma

Hamaidi I, Zhang L, Kim N, Wang MH, Iclozan C, Fang B, et al

Du J, Zhu M, Bao H, Li B, Dong Y, Xiao C, Zhang GY, Henter I, Rudorfer M, Vitiello B (2016) The role of nutrients in protecting mitochondrial function and neurotransmitter signaling: implications for the treatment of depression, PTSD, and suicidal behaviors

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Preclinical studies have confirmed that implementing time-restricted feeding (TRF) may partially reverse abnormal circadian rhythmic oscillations of clock genes and their target genes, as well as the dysregulation in expression or activity of metabolic regulatory proteins such as AMPK, mTOR, and CREB that frequently accompany these changes (Table 1)