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Furthermore, we discovered that the cytotoxicity of BSO is reduced following iNOS knockdown

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Thus, nuclear, mitochondrial, lysosomal, reticular, and other organelle-associated signaling and executive pathways are critical for RCD initiation and execution [20]

During infections, parasites are internalized into the phagolysosomal compartment and activate the NADPH oxidase 2 complex (Nox2) of the host macrophage [67]