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This syndrome comes with some nasty side effects, and can even result in coma or death

Comment Hepatocellular hypertrophy, secondary to increase in microsomal enzymes often occurs with a zonal or specific lobular pattern and commonly occurs following exposure to enzyme inducing xenobiotics

It has been reported that at least two DAMPs, namely mutant KRAS protein [172] and the DNA oxidation product 8-hydroxyguanosine/8-OHG [37], are released by ferroptotic cells to mediate macrophage polarization through the activation of AGER/RAGE (advanced glycosylation end-product specific receptor) and STING1/STING/TMEM173 (stimulator of interferon response cGAMP interactor 1) pathways, respectively

Withania somnifera suppresses tumor growth of intracranial allograft of glioma cells