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One suggestion of the metabolic substrate these cells can provide comes from the lactate shuttle hypothesis, which proposes that glial cells like astrocytes and Mller glia can uptake glucose and convert it to lactate to provide a metabolic substrate to RGCs (Hurley et al., 2015)

Pre-experiments revealed cytotoxic effects of roxadustat on neurons at concentrations of 50 M (Figure S5A), whereas the viability of astrocytes remained unaffected by roxadustat applied at a dose of 5 to 100 M (Figure S5B)

10.1007/s10787-017-0323-6 76 MihovilI.RadicB.BrcicL.BrcicI.VukojaI.IlicS.et al (2009)

How TB-500 Regulates Actin in Research How Peptide Reconstitution Works How Peptide Solution Stability Works What Is a Certificate of Analysis for Peptides

Ponadto odgrywaj strategiczn rol w aktywacji mierci komrek