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We previously demonstrated that the L585 residue of albumin promotes a structural destabilization in three regions of the C-terminal DIII domain, and thus, induces an intra-domain flexibility required for efficient FcRn binding 60

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Germfree (GF) mice subjected to kidney injury experience increased CD8 T-cell trafficking, inflammatory cytokine mediators, and worse disease course compared with normal wildtype (WT) mice

doi: 10.1002/elps.200800806