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Beyond the cerebellum: Perivascular space burden in spinocerebellar ataxia type 3 extends to multiple brain regions

In vivo , Bin-4 significantly reduces blood glucose and increases insulin and GLP-1 levels through this synergistic mechanism, providing a theoretical basis for the design of gas signaling molecule-based anti-diabetic drugs ( 7.2 The impact on fat metabolism Recent experiments have found that silybin directly downregulates the expression of key pro-inflammatory factors (such as TNF- and IL-1) by inhibiting the NF-B pathway, thereby reducing macrophage recruitment and inflammation mediator production in adipose tissue, and helping to restore the expression of the anti-inflammatory adipokine adiponectin

S., Masnic, F., Seck, S

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Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on dopamine metabolism in mouse and rat striatum