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Interestingly, in the Npc1 mouse model, the levels of infiltrating mononuclear cells are lower in the cerebellum relative to other brain regions, with no significant loss of neurons or oligodendrocytes

Normally, the SCN entrains peripheral clocks in various tissues via rhythmic oscillations of core clock genes such as CLOCK, BMAL1, PER, and CRY

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Despite encouraging findings in animal models, the translation of ferroptosis inhibitors into clinical application remains a formidable challenge

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