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Studies have shown that renal epithelial cells from patients with autosomal dominant polycystic kidney disease (ADPKD) exhibit increased sensitivity to IGF-1 compared to those from healthy individuals, indicating the involvement of this signaling pathway in cyst formation.71 In addition, increased expression of IGF-1-related genes, such as IGF-1, IGF1R, and IGFBP-5, along with the metalloproteinase Pregnancy-Associated Plasma Protein A (PAPPA), has been detected in kidney samples from PKD1 mutant mice, a model of PKD, compared to wild-type controls

252 Grape seed extract also reduced thrombus formation and spread in a rat model of DVT

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198 They also demonstrated that kaempferol exposure to Ishikawa cells inhibited cell migration and invasion by using scratch assay (wound healing) and perforation assay