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Additional research is needed to evaluate whether a compound that enhances GLT-1 expression and has good brain penetrance, favorable pharmacokinetic properties, and low risk of side effects and toxicity can be developed into a therapeutic drug [71]

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Lurie Childrens Hospital, 7 UPMC Children's Hospital of Pittsburgh, 8 Children's Hospital Los Angeles, 9 Riley Hospital for Children, 10 The Hospital for Sick Children Toronto, 11 University of Utah, 12 The Children's Hospital of Philadelphia, 13 University of Michigan Hospitals and Health Centers, 14 University of California, San Francisco, 15 University of Washington, 16 University of Colorado School of Medicine Background: Biliary atresia (BA) involves an aberrant immune response targeting cholangiocytes, resulting in prominent fibrosis early in life