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One of the most common characteristics of fibroids is the excessive production of extracellular matrix (ECM) components, which contributes to the stiffness and expansion of fibroids

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Together, this platform demonstrates that spatially controlled intracellular synthesis of PROTACs via tumor-targeted nano-assembly enhances degradation efficacy, overcomes the hook effect, and minimizes off-target toxicityproviding a robust and clinically promising strategy for precision protein degradation

Rodriguez, Ott, Michael, King, Glenn F