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Doctors may prescribe it for adults with obesity (a BMI of 30 or higher) or those who are overweight (a BMI of 27 or higher) and have other medical conditions such as diabetes, hypertension, and hypercholesterolemia

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The mitragynine-induced CB 1 receptor upregulations appeared to be attenuated by NIDA-41020 as seen in the immunohistochemical, protein, and mRNA studies