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doi:10.14310/HORM.2002.1276/METRICS 5

Taye BT

Proposed mechanisms of pathogenesis include stimulation of cellular necrosis and release of intracellular antigens resulting in systemic inflammation and IFN upregulation

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In this Review, we discuss how this advanced knowledge, aligned with new approaches, can enable effective translation of therapeutic agents from preclinical studies through to clinical benefit for patients with ALS