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NCOA4-mediated ferritinophagy participates in some physiological processes associated with iron metabolism in the cell, including erythropoiesis

Mukhtar et al., after analysing several meta-analyses, systematic reviews, and observational studies, concluded that the Western diet, rich in calories, refined sugar, and saturated fats contributed to cancer while the Mediterranean form of diet decreased cancer risk [181]

Microglial activation also triggers astrogliosis through the release of cytokines, which can exacerbate astrocytes reactive state, furthering neuronal injury

Apart from being unable to carry oxygen, this type of Hb causes oxidative and inflammatory damage to blood vessels [82]

The rats were housed in cages at a temperature of 23 1C and humidity of 75 5%, with a 12-h light/dark cycle and free access to food and water