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Statistical analysis and data graphing were performed using IBM SPSS 26.0, GraphPad Prism 8.0.1, and R 4.3.2

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Call your doctor if you experience any of the following symptoms: Headache Nausea Drowsiness Numbness Tingling in the arms and/or legs Seek immediate medical attention if you experience any of the following: Rash Itching Swelling Severe dizziness Trouble breathing Storage Store at controlled room temperature

Interestingly, in a process similar to step 1 of the CSD evolution in D2, modification of the canonical Ig disulfide between strands B and F has also occurred in D1 of some fish CD4 proteins (trout and fugu), which contain a distinct unpaired Cys in strand F, but lack the second Cys in strand B that forms a disulfide in mammalian and bird CD4 molecules