mitochondrial glutathione regulation and functions Controlling entry into mitochondria: potential roles for SLC25A39 in health (treatment of) disease Mitochondrial Glutathione, a Key Survival

Funding The US National Cancer Institute (of NIH), along with the American Institute for Cancer Research (Washington, DC), provided the initial funds

For statistical comparisons between two groups, we employed an unpaired two-tailed t test in GraphPad (Prism)

The process of validating biomarkers and identifying affinity reagents such as experimental substrate profiling, phage display, or aptamer selection via systematic evolution of ligands by exponential enrichment is effective but can be labor-intensive, expensive in a lab, and challenging

NAD + , the levels of which are known to decrease with aging 67 , promotes mitochondrial function and prolongs the lifespan of mice when its levels are increased through NAD precursors such as NR 68

Saturated fatty acids, MUFAs and PUFAs regulate ferroptosis