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The phase two trial, which had 40 patients, was conducted in Croatia, and some people question the validity of the study due to its location, but the groups conducting the trials seem to be doing robust, randomized, control, double-blind, placebo-control trials 2m6s

Yuriguchi M, Aoki H, Taguchi N, Kunisada T

Maldonado M, Chen J, Duan H, Huang T, Jiang G, Zhong Y (2021) High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restriction