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It also plays a role in energy homeostasis and cellular metabolism

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This marker is more accurate in assessing the biologically active fraction of vitamin B 12 in circulation than serum B 12 itself, and its level correlates well with the concentration of vitamin B 12 in erythrocytes (Valente et al., 2011)

These may include an increase in blood pressure and heart rate, difficulties with sleep such as insomnia, feelings of nervousness and restlessness, and the potential for dependence, abuse, or withdrawal symptoms with prolonged use

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