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Mitochondrial dysfunction could not be compensated by increasing oxidative phosphorylation, so that it was only compensated by activating the glycolytic pathway, which was inefficient at producing ATP (18)

Sleep disturbance, stress, inflammatory states, nutritional deficiencies, and reduced activity may not be the primary cause, but they can help maintain pain once PHN has become chronic

Based on the total induction of antioxidant enzymatic activity, the type of toxicological interaction in fish exposed to the mixture containing the lowest concentration of the two substances was addition in gills, and addition or synergism in the liver

10.1016/j.ejphar.2020.173554 157 WangJ.LiuY.LiX

However, safety is another concern with these treatments, especially if long lasting treatments are in place