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After 20 min of reduction 5 L of 0.1 mol/L BCPB in water was added to each sample to carry out the derivatization reaction

Reduction of SmTGR H571A by NADPH under acidic conditions The fully reduced SmTGR spectrum has proven difficult to obtain

doi:10.1002/humu.1380020302

Under conditions of excess glycine and low serine in colorectal cancer cells, the dominant SHMT reaction is the conversion of glycine to serine, which further depletes one-carbon units and inhibits nucleotide synthesis and proliferation (Labuschagne et al, 2014)