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Lactylation, a recently discovered important form of PTM, plays a key role in various IRI-related diseases, such as myocardial infarction, septic shock, and cerebral IRI [20, 37, 38]

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This is significant because, if a single valid vector can be identified (see below for criteria), it demonstrates that somatic and affective symptoms have a common core and, hence, a shared pathophysiology [25]