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Therefore, the observation that nitrotyrosine adducts are almost exclusively found inside mitochondria 18 suggests that superoxide is generated within the mitochondria and is not derived from other cellular sources

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The neurotoxic effects of activated microglia have been demonstrated in vivo

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One unit of catalase is defined as the amount of enzyme that decreases 0.1 of absorbance at 240 nm in 1 min

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