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Systematic reviews and meta-analyses suggest that frequent or prolonged prenatal exposure may be associated with (1925): Higher rates of hyperactivity and attention-related disorders Increased likelihood of ADHD medication use Elevated risk of autism -related neurobehavioral patterns Increased childhood asthma risk, particularly with late-pregnancy exposure A large systematic review of 46 studies found that neurodevelopmental risks appeared dose-dependent and were more pronounced in higher-quality studies (26)

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In OS, HSF1 is a target of interest since it supports malignancy through its involvement in proliferation, survival, and migration [25]