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Whenever possible, batch correction was enforced by providing the experimental group information in the model matrix, similarly to the RNA-seq analysis (Supplementary Data 5)

To evaluate the effects of HCA, testosterone propionate, Liproxstatin-1, and Brusatol on liver and kidney function-related biochemical markers in our experiments, we selected commonly used clinical markers for assessing liver and kidney function impairment, including AST, ALT, SCR, and UR levels

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