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Description

10.1126/science.7361101 75 MeinhardtS.VinkR

Activated neutrophils secrete myeloperoxidase (MPO), neutrophil elastase (NE), protease 3, histamine and matrix metalloproteinase 9 (MMP-9), all of which increase OxS, promote liver injury and the proliferation of hepatic stellate cells (HSCs), thereby increasing liver fibrosis 123,124