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Daily supplementation with Se at a supra-nutritional dose (200 g) results in significant reductions in mortality associated with total carcinomas of lung, prostate, and colon cancers without knowing how Se reduces the risk of cancer and if the GPx1 is involved in the action [42]

Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation

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Therefore, oxidative stress associated with deficient antioxidant defense is regarded as one of the key factors in the etiopathogenesis of RPL

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Sharpe A., Morley L.C., Tang T., Norman R.J., Balen A.H