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In practice, the clinical trials for cagrilintide report tolerability outcomes and adverse event patterns alongside efficacy endpoints, because these factors influence dose escalation and continuation within a protocol

A study examining the pharmacokinetics of benfotiamine treatment in Alzheimer's patients showed that maximum thiamine concentrations in the blood were reached 12h after a single dose of benfotiamine, while ThMP and ThDP peaked at later time points, between 3,5 and 8h for ThMP and 824h for ThDP