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In the case of GDM, it has been demonstrated that environmental factors, like diet, can influence gene expression involved in pathways related to nutrient metabolism, such as beta-oxidation, ketogenesis, and the one-carbon pathway

This could be explained by two main alternatives: (1) these adverse outcomes can be independent of gut microbiota or (2) the use of lithium may have some unexplored effects on gut microbiota that can explain the occurrence of some adverse outcomes that could be used for therapy monitoring in patients receiving this medication

The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets

70 SongX.ZhuS.ChenP.HouW.WenQ.LiuJ.et al (2018)

The second step after filtering was performed with 0.23 M Pt GSTF8 and varying dilutions of the first step reaction in buffer to cover substrate concentrations from 389 M to 6.5 M