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Centella is a herb mainly used in skincare for its healing properties

These actions have been reviewed herein, but of special mention during exercise is the recruitment of hippocampal neuroprogenitor cells and improved neuroglia function [289, 290]

1 H NMR (700 MHz, D 2 O) : 4.43 (d, J = 10.5 Hz, 1H, H 8 ), 4.36 (d, J = 10.5 Hz, 1H, H 8 ), 3.91 (s, 1H, H 2 ), 1.61 (s, 3H, H 9/10 ), 1.37 (s, 3H, H 9/10 )

Contains kojic acid, glutathione, and arbutin

Smad1 acts as a negative regulator of p53 acetylation by forming a ternary complex with p53 and p300, which inhibits the interaction between p300 and p53, reduces p53 acetylation, and Enhances Smad1 self-acetylation at K373, an essential modification for its oncogenic function, thereby promoting tumor growth and chemoresistance (Gong et al., 2025)